Clinical outcomes of cryptozoospermic patients undergoing surgical sperm retrieval

Introduction Cryptozoospermia is defined by the World Health Organization (WHO) as presence of isolated sperm cell in ejaculate only identified after an extended microscopic search or being pelleted. Although number spermatozoa usually sufficient for intracytoplasmic injection (ICSI), ICSI fails due to poor quality some cases. Contention remains regarding whether testicular offers any advantage this unique situation. At our tertiary referral center, we will offer patients a surgical retrieval via conventional microdissection extraction (microTESE) men with cryptozoospermia and failed ICSI, where ejaculated specimens are immotile insufficient ICSI. In study, sought describe experience evaluate predictors success cryptozoospermic who had microTESE at center. Methods We retrospectively reviewed electronic medical records all underwent between 2007- 2021 deemed be (e.g., nonmotile sperm). evaluated demographics, preoperative lab results, pathology rate (SRR) outcomes. Results 28 were identified. These 37 microTESE. 22 these previous treatment sperm, while other 6 non-suitable None genetic abnormalities. Successful motile suitable was achieved 30 micro TESE procedures (SRR: 81.0%).14 out (50%) embryo transfer positive pregnancy result, 12/28 (42.8%) successful live birth. The most common pathological pattern hypospermatogenesis found 65.3% (17/26). Fibrosis significantly higher negative group. There no postoperative complications noted. Disscussion use prior using has high While still controversial, results suggest that viable option minimal risk complications.